Enhancing the Supportive Care of Patients with Cancer

Improving the Patient Experience

enterade® is an amino acid-based, glucose free, medical food that is lightly sweetened with stevia leaf extract. enterade® provides select amino acids and electrolytes (sodium and potassium)—the nutrients needed to rebuild the villi and protect the GI tract and deliver total body hydration for patients undergoing treatment for cancer.

Entrinsic Health Solutions’ mission is to address the critical digestive, nutritional, and hydration related side effects that patients may face as a result of cancer treatment. Our focus is supportive care. We are committed to preventing and reducing these treatment side effects so that patients can feel better, fight back, and remain on necessary therapy.

A 155 subject pragmatic study in partnership with 21st Century Oncology demonstrated that patients who used enterade® for more than 7 days reported a 78% improvement in their cancer treatment side effects (composite endpoint: diarrhea, nausea, dehydration, weight maintenance and malaise).1 This study also revealed that patients who used enterade® between 1-6 days reported a 44% improvement in symptoms, compared to a 7% improvement without using enterade® (p<0.001).1

Patient reported diarrhea, as a univariate endpoint, improved in 78% of patients who used enterade® for more than 7 days, compared to 48% reported improvement with 1-6 day usage, and only 10% of patients who did not use enterade® (p<0.001).1 enterade® also provided an 88% patient reported improvement in hydration, when used for more than 7 days (p<0.02).1

Supportive Care Through Amino Acids

Superior Nutrient and Electrolyte Absorption
After years of research, Entrinsic Health Solutions has evaluated each amino acid for its absorptive capabilities, tight barrier function and cellular regeneration to create a proprietary Amino Acid Coupled Transport (A2CT) technology. The select amino acids and electrolytes (sodium and potassium) in enterade’s® Advanced Oncology Formula help to rebuild the damaged GI absorptive structures, protect the GI by tightening the gut barrier, and provide total body hydration.

Amino acids in enterade® do not have the secretory effect of chloride and will not have a deleterious effect on diarrhea. Amino acids in enterade® have shown to reduce paracellular permeability, therefore reducing antigenic translocation. These select amino acids do not dissociate from sodium in the vascular space, as they carry the electrolyte and fluids from the vascular into the intracellular and interstitial space, providing hydration of all three fluid compartments.

The enterade® Advanced Oncology Formula was created with 5 specifically selected amino acids based on their absorptive capacity, tightening of the barrier function and cellular repair capabilities, enhancing healthy immune function. Preclinical data has shown that providing the wrong amino acids in a mixture could have deleterious effects, such as decreased survival and weight loss.14

Additionally, it has been proven that changing the composition of the amino acid mixture by taking or adding a single amino acid could have a significant effect on the efficacy and performance of the remaining amino acids. In this same study, Aspartic Acid, Valine, Serine, Threonine, and Tyrosine all showed an increase in electrolyte absorption, no effect on chloride secretion, and decreased paracellular permeability.14

The Select Amino Acids in enterade® Advanced Oncology Formula Support Long Term Digestive Health in 3 Ways:

Rebuilds: Promotes proliferation, maturation, and migration of cells in damaged GI epithelium

Protects: Reduces paracellular permeability, reduces antigen and bacterial translocation across the barrier

Hydates: Helps replenishs sodium and fluid absorption in cells and does not increase chloride secretion. Provides superior fluid & electrolyte transport compared to glucose-based systems