The efficacy of different commercial beverage compositions for meeting oral rehydration therapy (ORT) goals in the treatment of acute dehydration in healthy humans has not been systematically tested. The objective of the study was to compare fluid retention, plasma volume (PV), and interstitial fluid (ISF) volume restoration when using 1 popular glucose‐based and 1 novel amino acid–based (AA) commercial ORT beverage following experimental hypertonic or isotonic dehydration.

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